qch - Query Composite Hypotheses
Provides functions for the joint analysis of Q sets of
p-values obtained for the same list of items. This joint
analysis is performed by querying a composite hypothesis, i.e.
an arbitrary complex combination of simple hypotheses, as
described in Mary-Huard et al. (2021)
<doi:10.1093/bioinformatics/btab592> and De Walsche et
al.(2023) <doi:10.1101/2024.03.17.585412>. In this approach,
the Q-uplet of p-values associated with each item is
distributed as a multivariate mixture, where each of the 2^Q
components corresponds to a specific combination of simple
hypotheses. The dependence between the p-value series is
considered using a Gaussian copula function. A p-value for the
composite hypothesis test is derived from the posterior
probabilities.
