Package: qch 2.0.0

qch: Query Composite Hypotheses

Provides functions for the joint analysis of Q sets of p-values obtained for the same list of items. This joint analysis is performed by querying a composite hypothesis, i.e. an arbitrary complex combination of simple hypotheses, as described in Mary-Huard et al. (2021) <doi:10.1093/bioinformatics/btab592> and De Walsche et al.(2023) <doi:10.1101/2024.03.17.585412>. In this approach, the Q-uplet of p-values associated with each item is distributed as a multivariate mixture, where each of the 2^Q components corresponds to a specific combination of simple hypotheses. The dependence between the p-value series is considered using a Gaussian copula function. A p-value for the composite hypothesis test is derived from the posterior probabilities.

Authors:Tristan Mary-Huard [aut, cre], Annaig De Walsche [aut], Franck Gauthier [ctb]

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5 exports 0.09 score 54 dependencies 218 downloads

Last updated 6 months agofrom:cbf2b368ab. Checks:OK: 9. Indexed: yes.

Exports:GetH1AtLeastGetH1EqualGetHconfigqch.fitqch.test

Dependencies:ADGofTestclicolorspacecopuladplyrfansifarverFNNgenericsggplot2gluegslgtableisobandkernlabKernSmoothkslabelinglatticelifecyclemagrittrMASSMatrixmclustmgcvmulticoolmunsellmvtnormnlmenumDerivpcaPPpillarpkgconfigplyrpracmapsplinepurrrqvalueR6RColorBrewerRcppRcppArmadilloreshape2rlangscalesstablediststringistringrtibbletidyselectutf8vctrsviridisLitewithr